LIGNOCAINE INFUSION FOR NEUROPATHIC ITCH IN PATIENT WITH NEUROFIBROMATOSIS: Received 2024-02-29; Accepted 2024-06-26; Published 2025-01-02

Nadia Mohd Mustafah; Wan Nabilah Nik Nabil; Awisul Islah Ghazali

doi:10.22452/jummec.vol28no1.7

LIGNOCAINE INFUSION FOR NEUROPATHIC ITCH IN PATIENT WITH NEUROFIBROMATOSIS

Received 2024-02-29; Accepted 2024-06-26; Published 2025-01-02

Authors

Nadia Mohd Mustafah Pain Management Clinic, Department of Anesthesiology and Intensive Care, Hospital Taiping, 34000 Taiping, Perak, Malaysia.
Wan Nabilah Nik Nabil Department of Anesthesiology and Intensive Care, Hospital Kuala Lumpur, Jalan Pahang, 50586 Kuala Lumpur, Malaysia.
Awisul Islah Ghazali Pain Management Clinic, Department of Anesthesiology and Intensive Care, Hospital Taiping, 34000 Taiping, Perak, Malaysia.

DOI:

https://doi.org/10.22452/jummec.vol28no1.7

Abstract

Neurofibromatosis (NF) is an autosomal dominant neurocutaneous disorder. The itchiness suffered by patients with NF is possibly caused by mast cells. However, transient receptor potential ankyrin 1 (TrpA1) and transient receptor potential vanilloid 1 (TrpV1) have been recently discovered as mediators of itchiness and pain in patients with NF. We reported a patient with NF, afflicted by neuropathic pain and itch, despite despite receiving conservative treatment. Herein, we provided the patient lignocaine infusion, which improved her pain and itch score by 50%. Additionally, her sleep quality, ability to perform housework and engagement in leisure activities were improved. This case report highlights the therapeutic value of lignocaine infusion when conservative treatment is ineffective for chronic neuropathic itch in patients with neurofibromatosis through suppressing TrpA1 and TrpV1.

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Published

2025-01-02

Issue

Vol. 28 No. 1 (2025)

Section

Research article

License

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